Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539159 | 0.83 | CHEK1 (0.67) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL29531075 | 0.83 | CHEK1 (0.67) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL28884515 | 0.83 | CHEK1 (0.67) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL28884514 | 0.83 | CHEK1 (0.67) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL5498217 | 0.83 | CHEK1 (0.67) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL5250115 | 0.83 | KDR (1.00) | KDRCHEK1FGFR1LCK | |
| SCHEMBL31249528 | 0.82 | CHEK1 (0.69) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL31249517 | 0.82 | CHEK1 (0.69) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL29683745 | 0.82 | CHEK1 (0.64) | KDRCHEK1FGFR1NTRK1NTRK2 | |
| SCHEMBL5250216 | 0.82 | CHEK1 (0.64) | KDRCHEK1FGFR1NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745035-A1 | POLYMORPHIC AND AMORPHOUS FORMS OF 2,5-DIMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID-{2-FLUORO-5-¬3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YLAMINO|-PHENYL}-AMIDE | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |