Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540579 | 0.91 | DGAT1 (0.82) | DGAT1HTTKMT2A | |
| SCHEMBL3547014 | 0.90 | DGAT1 (0.75) | DGAT1HTTMEN1KMT2A | |
| SCHEMBL3547406 | 0.89 | DGAT1 (0.73) | DGAT1HTTKMT2A | |
| SCHEMBL3537324 | 0.89 | DGAT1 (0.73) | DGAT1HTTKMT2A | |
| SCHEMBL3540550 | 0.88 | DGAT1 (0.78) | DGAT1HTTKMT2A | |
| SCHEMBL3543069 | 0.88 | DGAT1 (0.65) | DGAT1HTT | |
| SCHEMBL3544685 | 0.87 | DGAT1 (0.79) | DGAT1MEN1KMT2A | |
| SCHEMBL3538069 | 0.86 | DGAT1 (0.78) | DGAT1HTTKMT2A | |
| SCHEMBL3545486 | 0.86 | DGAT1 (0.77) | DGAT1HTTKMT2A | |
| SCHEMBL3544733 | 0.84 | DGAT1 (0.75) | DGAT1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |