Tryptophan

Tryptophan

SCHEMBL525100

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.c1ccsc1

nearest known ligand 0.84

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.84
MAPT P10636 3/20 0.84
KMT2A Q03164 3/20 0.84
LMNA P02545 2/20 0.84
TSHR P16473 2/20 0.84
BLM P54132 2/20 0.84
PMP22 Q01453 2/20 0.84
MEN1 O00255 2/20 0.84
MPO P05164 1/20 0.84
HIF1A Q16665 1/20 0.84
SMN1; SMN2 Q16637 1/20 0.60
APAF1 O14727 1/20 0.59
POLB P06746 1/20 0.59
RECQL P46063 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
HTR2A P28223 3/20 0.59
HTR1A P08908 2/20 0.59
HTR2C P28335 2/20 0.59
SLC6A4 P31645 2/20 0.59
HTR7 P34969 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Tryptophan SCHEMBL289042 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL1120026 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL7327 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL475350 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL4732053 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL23141133 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL19161120 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL4732052 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL475349 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL289043 0.92 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4069789-B1 LOW SOLVENT COATING COMPOSITION AKZO NOBEL COATINGS INT BV (NL) 2024-05-22 EP disclosed
US-11577212-B2 Stimuli-responsive micro-reservoirs for release of encapsulants SAS Nanotechnologies Inc. (US) 2023-02-14 US disclosed
WO-2021110829-A1 LOW SOLVENT COATING COMPOSITION AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) 2021-06-10 WO disclosed
EP-3823745-A1 STIMULI-RESPONSIVE MICRO-RESERVOIRS FOR RELEASE OF ENCAPSULANTS SAS Nanotechnologies LLC (US) 2021-05-26 EP disclosed
WO-2020018555-A1 STIMULI-RESPONSIVE MICRO-RESERVOIRS FOR RELEASE OF ENCAPSULANTS SAS Nanotechnologies LLC (US) 2020-01-23 WO disclosed
EP-2414464-B1 ANTI-CORROSIVE COATING COMPOSITION AKZO NOBEL COATINGS INT BV (NL) 2013-08-28 EP disclosed
EP-2414464-A1 ANTI-CORROSIVE COATING COMPOSITION Akzo Nobel Coatings International B.V. (NL) 2012-02-08 EP disclosed
US-20120025142-A1 ANTI-CORROSIVE COATING COMPOSITION AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) 2012-02-02 US disclosed
WO-2010112605-A1 ANTI-CORROSIVE COATING COMPOSITION AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) 2010-10-07 WO disclosed
CN-1241924-C Method for preparing enkephalinase and angiotensin-converting enzyme inhibitor intermediate and its intermediate AVENTIS PHARMACEUTICALS CORP (US) 2006-02-15 CN disclosed
CN-1495186-A Method for preparing enkephalinase and angiotensin-converting enzyme inhibitor intermediate and its intermediate ���µ�˹ҩ�﹫˾ 2004-05-12 CN disclosed
CN-1113894-C Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof AVENTIS PHARMA INC (US) 2003-07-09 CN disclosed
CN-1170413-A Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof HOECHEST MARION ROUSSEL INC (US) 1998-01-14 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11577212-B2 Stimuli-responsive micro-reservoirs for release of encapsulants ORAI1, CD44, VAPA KDM4E 2671/4885MAPT 3648/4885KMT2A 4121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.