Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.54 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.53 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12504017 | 0.91 | ITGAV (0.81) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL14608716 | 0.90 | ITGAV (0.66) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7431994 | 0.90 | ITGAV (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7435542 | 0.90 | ITGAV (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7440869 | 0.90 | ITGAV (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6108253 | 0.88 | ITGAV (0.77) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL6108257 | 0.88 | ITGAV (0.77) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL5251715 | 0.88 | ITGAV (0.63) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL5248211 | 0.88 | ITGAV (0.63) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL5251867 | 0.84 | ITGAV (0.56) | ITGAVITGB3ITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219609-B1 | AROMATIC NITROGENOUS SIX-MEMBERED RING COMPOUNDS | TANABE SEIYAKU CO (JP) | 2007-04-04 | — | — | EP | claimed |
| EP-1219609-B1 | AROMATIC NITROGENOUS SIX-MEMBERED RING COMPOUNDS | TANABE SEIYAKU CO (JP) | 2007-04-04 | — | — | EP | disclosed |
| EP-1315501-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1315501-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-7056909-B2 | Alpha v integrin receptor antagonists | MERCK & CO., INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1315501-A4 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-03-23 | — | — | EP | disclosed |
| US-20040038963-A1 | Alpha v integrin receptor antagonists | MERCK SHARP & DOHME CORP. | 2004-02-26 | — | — | US | disclosed |
| EP-1315501-A1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6410526-B1 | BONE DISORDERS; RESTENOSIS; VISION DISORDERS; ANTICHOLESTEROL AGENTS; ANTICANCER, ANTITUMOR AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |
| WO-2002007730-A1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038963-A1 | Alpha v integrin receptor antagonists | ITGAV, ADGRE5, ITGB3 | ITGAV 1/4885ITGB3 3/4885ITGA2B 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.