Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 2/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583467 | 0.92 | ABL1 (0.51) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL17262961 | 0.82 | ABL1 (0.46) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL5251355 | 0.75 | KDR (0.54) | ABL1RETMAP4K4FLT3RAB9A | |
| SCHEMBL4968126 | 0.74 | CYP3A4 (0.58) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL26886953 | 0.73 | ASIC3 (0.44) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL3572562 | 0.72 | MAP4K4 (0.53) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL4717142 | 0.71 | APP (0.58) | RETPIK3CAMTORPDK1ADK | |
| SCHEMBL9611202 | 0.70 | FFAR1 (0.59) | PIK3CAMTORPDK1ASIC3FFAR1 | |
| SCHEMBL3581835 | 0.69 | PIK3CA (0.44) | ABL1RETPIK3CAMTORPDK1 | |
| SCHEMBL4719248 | 0.69 | PTPN11 (0.50) | ABL1RETMAP4K4FLT3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |