Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246521 | 0.87 | ATM (0.42) | MAPK1ATMNPSR1DHODHTSHR | |
| SCHEMBL5739924 | 0.80 | SMN1; SMN2 (0.53) | MAPK1SMN1; SMN2ATMNPSR1DHODH | |
| SCHEMBL4713629 | 0.75 | KDM4E (0.47) | MAPK1ATMNPSR1DHODHTSHR | |
| SCHEMBL4717637 | 0.74 | ALDH1A1 (0.53) | MAPK1SMN1; SMN2ATMNPSR1TSHR | |
| SCHEMBL4712870 | 0.73 | ALDH1A1 (0.45) | MAPK1SMN1; SMN2ATMNPSR1DHODH | |
| SCHEMBL5253599 | 0.72 | ALDH1A1 (0.41) | ATMNPSR1DHODHTSHRALDH1A1 | |
| SCHEMBL4710915 | 0.70 | MAPK1 (0.46) | MAPK1SMN1; SMN2NPSR1DHODHALDH1A1 | |
| SCHEMBL5739195 | 0.70 | ALDH1A1 (0.41) | ATMNPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL1542104 | 0.69 | SMN1; SMN2 (0.55) | MAPK1SMN1; SMN2ATMNPSR1TSHR | |
| SCHEMBL4710883 | 0.67 | ALDH1A1 (0.41) | SMN1; SMN2ATMNPSR1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004005287-A9 | PYRAZOLOISOQUINOLINE DERIVATIVES FOR INHIBITING NFKAPPAB-INDUCING KINASE (NIK) | AVENTIS PHARMA GMBH (DE) | 2004-03-04 | — | — | WO | claimed |
| EP-1519934-B1 | PYRAZOLOISOQUINOLINE DERIVATIVES FOR INHIBITING NF$G(K)B-INDUCING KINASE (NIK) | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2004005287-A9 | PYRAZOLOISOQUINOLINE DERIVATIVES FOR INHIBITING NFKAPPAB-INDUCING KINASE (NIK) | AVENTIS PHARMA GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |