SCHEMBL5253176

SCHEMBL5253176

CNC(=O)ON1CCc2c(c(-c3ccc(Cl)cc3)nn2CC(O)CN2CCN(c3ccccc3C)CC2)C1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSS P25774 18/20 0.64
ABCB1 P08183 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5254913 0.93 CTSS (0.63) CTSSABCB1
SCHEMBL5254712 0.93 CTSS (0.62) CTSSABCB1
SCHEMBL5255138 0.93 CTSS (0.72) CTSS
SCHEMBL5253805 0.92 CTSS (0.61) CTSSABCB1
SCHEMBL5252199 0.91 CTSS (0.67) CTSSABCB1
SCHEMBL5251821 0.90 CTSS (0.64) CTSSABCB1
SCHEMBL5251471 0.90 CTSS (0.58) CTSSABCB1
SCHEMBL5257157 0.89 CTSS (0.60) CTSSABCB1
SCHEMBL2984998 0.87 CTSS (0.73) CTSS
SCHEMBL2972647 0.85 CTSS (0.69) CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309591-B1 SUBSTITUTED PYRAZOLES ORTHO MCNEIL PHARM INC (US) 2007-01-24 EP claimed