Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940077 | 0.86 | USP30 (0.49) | PRMT5WDR77GPR119USP30NAMPT | |
| SCHEMBL2707784 | 0.83 | GPR119 (0.52) | PRMT5WDR77GPR119NAMPTMAPK1 | |
| SCHEMBL2675407 | 0.80 | USP30 (0.48) | PRMT5WDR77GPR119USP30NAMPT | |
| SCHEMBL4114242 | 0.79 | USP30 (0.47) | PRMT5WDR77GPR119USP30NAMPT | |
| SCHEMBL19272766 | 0.77 | TSHR (0.59) | PRMT5WDR77GPR119USP30MAPK1 | |
| SCHEMBL30958416 | 0.77 | GPR119 (0.43) | PRMT5WDR77GPR119NAMPTMAPK1 | |
| SCHEMBL2676089 | 0.77 | GPR119 (0.50) | PRMT5WDR77GPR119NAMPTMAPK1 | |
| SCHEMBL4118999 | 0.76 | GPR119 (0.49) | PRMT5WDR77GPR119NAMPTKDM4E | |
| SCHEMBL25387773 | 0.75 | PRMT5 (0.54) | PRMT5WDR77GPR119USP30NAMPT | |
| SCHEMBL25385985 | 0.75 | PRMT5 (0.54) | PRMT5WDR77GPR119USP30NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |