Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.47 |
| ▸ | MAT2A | P31153 | 6/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945192 | 0.83 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11CHRNB2 | |
| SCHEMBL2945196 | 0.82 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11CHRNB2 | |
| SCHEMBL1066845 | 0.79 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL5257300 | 0.73 | RXFP1 (0.36) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL1061199 | 0.73 | MAT2A (0.44) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL1065129 | 0.73 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL2942597 | 0.72 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1065189 | 0.72 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL1060298 | 0.71 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAT2A | |
| SCHEMBL1064632 | 0.70 | MAT2A (0.52) | MAPK14MAPK13MAPK12MAPK11MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333833-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-10-24 | — | — | EP | disclosed |
| EP-1333833-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002059083-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-01 | — | — | WO | disclosed |