Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13436251 | 0.86 | TNK2 (0.55) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL3565845 | 0.79 | AURKA (0.49) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL6748429 | 0.76 | KDM4E (0.63) | TNK2KDRALDH1A1HPGDCHEK1 | |
| SCHEMBL3051089 | 0.76 | TNK2 (0.45) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL3569303 | 0.74 | TNK2 (0.37) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL3566807 | 0.69 | TNK2 (0.63) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL3630335 | 0.69 | ALDH1A1 (0.45) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL13436256 | 0.67 | TNK2 (0.67) | TNK2LCKKDRJAK3EGFR | |
| SCHEMBL3572697 | 0.67 | TNK2 (0.68) | TNK2LCKKDRJAK3AURKA | |
| SCHEMBL735560 | 0.66 | TNK2 (0.68) | TNK2AURKAALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791845-A2 | FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS | AMGEN INC. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006130160-A2 | FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS | AMGEN INC. (US) | 2006-12-07 | — | — | WO | disclosed |