Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | F2R | P25116 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508276 | 1.00 | MAPK1 (0.58) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3060655 | 0.99 | MAPK1 (0.57) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL11507396 | 0.87 | TAAR1 (0.51) | MAPK1ALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL22889047 | 0.86 | MAPK1 (0.55) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL21349100 | 0.84 | MAPK1 (0.66) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL4197894 | 0.82 | MAPK1 (0.64) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL7475224 | 0.82 | MAPK1 (0.64) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL7565149 | 0.82 | MAPK1 (0.81) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL12569392 | 0.82 | MAPK1 (0.59) | MAPK1LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL4129269 | 0.81 | MAPK1 (0.62) | MAPK1LMNAMAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833831-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069258-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-06-29 | — | — | WO | disclosed |