SCHEMBL525458

SCHEMBL525458

CC1(C=O)COC(=O)C1O

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL152955 0.74
SCHEMBL1164270 0.74
SCHEMBL1164243 0.74
SCHEMBL24296294 0.71
SCHEMBL29022227 0.69 PRKCA (0.33) LMNA
SCHEMBL4818783 0.69 PRKCA (0.33) LMNA
SCHEMBL11009008 0.68
Ethylene Glycol SCHEMBL15768432 0.65
SCHEMBL10442863 0.65 PRKCA (0.33)
SCHEMBL18022218 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113816932-B Synthesis of keto pantolactone 宁夏优维生物科技有限公司 2023-03-17 CN claimed
CN-115975964-A High-activity ketopantolactone reductase mutant and coding gene and application thereof 万华化学(四川)有限公司 2023-04-18 CN disclosed
CN-115851642-A Ketone group pantoic acid lactone reductase and application thereof 杭州鑫富科技有限公司 2023-03-28 CN disclosed
CN-115851642-A Ketone group pantoic acid lactone reductase and application thereof 杭州鑫富科技有限公司 2023-03-28 CN disclosed
CN-113816932-B Synthesis of keto pantolactone 宁夏优维生物科技有限公司 2023-03-17 CN disclosed
CN-113816932-B Synthesis of keto pantolactone 宁夏优维生物科技有限公司 2023-03-17 CN disclosed
CN-113816932-B Synthesis of keto pantolactone 宁夏优维生物科技有限公司 2023-03-17 CN disclosed
CN-114934061-A Engineering bacteria and application thereof in producing D-pantolactone by full-cell catalysis of keto-pantolactone 中国科学院微生物研究所 2022-08-23 CN disclosed
CN-114085820-A Ketopantolactone reductase derived from Candida viswanathii 万华化学集团股份有限公司 2022-02-25 CN disclosed
CN-113816932-A Synthesis method of keto pantolactone 宁夏优维生物科技有限公司 2021-12-21 CN disclosed
CN-113816932-A Synthesis method of keto pantolactone 宁夏优维生物科技有限公司 2021-12-21 CN disclosed
CN-113816932-A Synthesis method of keto pantolactone 宁夏优维生物科技有限公司 2021-12-21 CN disclosed
CN-105950679-B Method for preparing D-pantolactone by fermentation 江西兄弟医药有限公司 2019-12-10 CN disclosed
WO-2012014228-A1 A METHOD TO BY-PASS ALLOSTERIC DOMAIN ACTIVITY OF AN ENZYME SO AS TO ALTER ITS FEEDBACK OR FEED-FORWARD INHIBITION OR ACTIVATION SINGH ABHISHEK NARAIN (IN) 2012-02-02 WO disclosed
EP-0460240-B1 CATALYST FOR HYDROGENATION, DEHYDROSILYLATION OR HYDROSILYLATION, AND ITS USE SAGAMI CHEM RES (JP) 1994-11-09 EP disclosed
US-5182246-A Complex metal carbonyl SAGAMI CHEMICAL RESEARCH CENTER (JP) 1993-01-26 US disclosed
EP-0460240-A1 CATALYST FOR HYDROGENATION, DEHYDROSILYLATION OR HYDROSILYLATION, AND ITS USE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-12-11 EP disclosed
EP-0336123-A2 New chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 1989-10-11 EP disclosed