Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 20/20 | 0.81 |
| ▸ | HTR1A | P08908 | 18/20 | 0.81 |
| ▸ | HTR2A | P28223 | 18/20 | 0.81 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262972 | 1.00 | DRD2 (0.81) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5249321 | 0.95 | DRD2 (0.73) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5363562 | 0.93 | DRD2 (0.79) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5258353 | 0.91 | DRD2 (0.76) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5216423 | 0.90 | DRD2 (0.94) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5367118 | 0.90 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5372292 | 0.88 | DRD2 (0.71) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5366815 | 0.87 | DRD2 (0.95) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5260277 | 0.87 | DRD2 (0.80) | DRD2HTR1AHTR2ADRD1DRD4 | |
| SCHEMBL5255180 | 0.87 | DRD2 (0.80) | DRD2HTR1AHTR2ADRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869041-A1 | TETRAHYDRO-PYRIDOAZEPIN-8-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006103559-A1 | TETRAHYDRO-PYRIDOAZEPIN-8-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |