Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371053 | 0.93 | HDAC1 (0.58) | HDAC1HDAC2LSSHDAC3HDAC4 | |
| SCHEMBL7373189 | 0.93 | HDAC1 (0.58) | HDAC1HDAC2LSSHDAC3HDAC4 | |
| SCHEMBL96854 | 0.88 | KCNA3 (0.62) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL96602 | 0.82 | KCNA3 (0.67) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL13420978 | 0.81 | ALDH1A1 (0.60) | HDAC1HDAC2LSSHDAC3HDAC4 | |
| SCHEMBL7500091 | 0.81 | KCNA3 (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL5593684 | 0.81 | KCNA3 (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL9683773 | 0.81 | KCNA3 (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2786288 | 0.81 | KCNA3 (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL1172269 | 0.81 | KCNA3 (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1221440-B1 | Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators | OTSUKA PHARMA CO LTD (JP) | 2007-04-25 | — | — | EP | disclosed |
| US-6642223-B2 | A benzoazepin or benzodiazepin derivatives, shows excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as antagonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-11-04 | — | — | US | disclosed |
| EP-0765314-B1 | BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS | OTSUKA PHARMA CO LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| EP-1221440-A1 | Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators | Otsuka Pharmaceutical Company, Limited (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-20020049194-A1 | Benzoheterocyclic derivatives | OGAWA HIDENORI (JP) | 2002-04-25 | — | — | US | disclosed |
| US-6335327-B1 | Benzoheterocyclic derivatives | OTSUKA PHARMACEUTICALS CO., LTD. (JP) | 2002-01-01 | — | — | US | disclosed |
| US-6096735-A | Benzoheterocyclic derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0765314-A1 | BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034540-A1 | BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049194-A1 | Benzoheterocyclic derivatives | AVPR2, AVPR1A, AVPR1B | HDAC1 545/4885HDAC2 803/4885LSS 1788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.