Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.77 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | QPCT | Q16769 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACG | P22612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991182 | 0.95 | GSK3B (0.75) | GSK3BKDRFLT3QPCTPRKACA | |
| SCHEMBL5257432 | 0.91 | GSK3B (0.77) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL5257465 | 0.90 | GSK3B (0.75) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL5258462 | 0.89 | GSK3B (0.75) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL4992178 | 0.89 | GSK3B (0.75) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL4994614 | 0.88 | GSK3B (0.72) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL5260235 | 0.87 | GSK3B (1.00) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL4984745 | 0.87 | GSK3B (0.70) | GSK3BKDRPRKCA | |
| SCHEMBL5256402 | 0.82 | GSK3B (0.65) | GSK3BKDRPRKCA | |
| SCHEMBL4991290 | 0.78 | GSK3B (0.62) | GSK3BFLT3PRKCAPRKACAPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |