Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.65 |
| ▸ | PRKCA | P17252 | 7/20 | 0.48 |
| ▸ | PRKCB | P05771 | 2/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984745 | 0.87 | GSK3B (0.70) | GSK3BPRKCACDK2CCNE2CDK4 | |
| SCHEMBL5257465 | 0.85 | GSK3B (0.75) | GSK3BPRKCAKDR | |
| SCHEMBL5255284 | 0.82 | GSK3B (0.77) | GSK3BPRKCAKDR | |
| SCHEMBL5257432 | 0.82 | GSK3B (0.77) | GSK3BPRKCAKDR | |
| SCHEMBL4991182 | 0.81 | GSK3B (0.75) | GSK3BKDR | |
| SCHEMBL4992178 | 0.81 | GSK3B (0.75) | GSK3BPRKCAPRKCBPRKCECDK4 | |
| SCHEMBL5258462 | 0.81 | GSK3B (0.75) | GSK3BPRKCAPRKCBPRKCHPRKCE | |
| SCHEMBL4991290 | 0.80 | GSK3B (0.62) | GSK3BPRKCAPRKCBPRKCHPRKCE | |
| SCHEMBL4994614 | 0.79 | GSK3B (0.72) | GSK3BPRKCAPRKCBPRKCHPRKCE | |
| SCHEMBL5260235 | 0.79 | GSK3B (1.00) | GSK3BPRKCAPRKCBPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |