SCHEMBL5256189

SCHEMBL5256189

CSN1CCc2c(c(-c3ccc(Br)cc3)nn2CC(O)CN2CCC(c3c[nH]c4ncccc34)CC2)C1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSS P25774 20/20 0.78
CD74 P04233 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5252335 0.88 CTSS (0.79) CTSS
SCHEMBL5255034 0.88 CTSS (1.00) CTSSCD74
SCHEMBL5251583 0.80 CTSS (0.81) CTSSCD74
SCHEMBL4769833 0.79 CTSS (1.00) CTSSCD74
SCHEMBL5257061 0.77 CTSS (0.59) CTSS
SCHEMBL5252121 0.76 CTSS (0.79) CTSS
SCHEMBL5251651 0.75 CTSS (1.00) CTSSCD74
SCHEMBL5254294 0.74 CTSS (0.84) CTSSCD74
SCHEMBL4764801 0.72 CTSS (1.00) CTSSCD74
SCHEMBL7128189 0.72 CTSS (0.56) CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309592-B9 SUBSTITUTED PYRAZOLES ORTHO MCNEIL PHARM INC (US) 2007-02-28 EP claimed
EP-1309592-B1 SUBSTITUTED PYRAZOLES ORTHO MCNEIL PHARM INC (US) 2006-04-26 EP claimed