⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11769800 | 0.79 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL23135474 | 0.79 | SMN1; SMN2 (0.61) | — | |
| SCHEMBL16747754 | 0.78 | — | — | |
| SCHEMBL12859514 | 0.78 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL20629378 | 0.77 | HPGD (0.42) | — | |
| SCHEMBL20852781 | 0.76 | HPGD (0.39) | — | |
| SCHEMBL26091851 | 0.76 | SMN1; SMN2 (0.68) | — | |
| SCHEMBL26731332 | 0.75 | HPGD (0.44) | — | |
| SCHEMBL26731397 | 0.75 | HPGD (0.41) | — | |
| SCHEMBL10015682 | 0.75 | SMN1; SMN2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809341-B2 | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents | RIGEL PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| EP-1448551-B1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | OSI PHARM INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1615910-A1 | PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY)-PHENYLAMINO)QUINAZOLINYL)-ALLYL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES | Pfizer Products Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050026940-A1 | Processes for the preparation of substituted bicyclic derivatives | PFIZER INC | 2005-02-03 | — | — | US | disclosed |
| WO-2004089934-A1 | PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES | PFIZER PRODUCTS INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| EP-1448551-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003045939-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-05 | — | — | WO | disclosed |