Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.56 |
| ▸ | IGF1R | P08069 | 5/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224280 | 0.91 | MAP2K1 (0.58) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3228827 | 0.87 | IGF1R (0.59) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3221719 | 0.85 | MAP2K1 (0.61) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3231921 | 0.84 | MAP2K1 (0.64) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3219604 | 0.83 | MAP2K1 (0.71) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL6740482 | 0.83 | MAP2K1 (0.60) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3228928 | 0.83 | MAP2K1 (0.70) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3224442 | 0.82 | MAP2K1 (0.70) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3227776 | 0.82 | MAP2K1 (0.62) | MAP2K1IGF1REGFRIKBKBLYN | |
| SCHEMBL3232470 | 0.81 | IGF1R (0.59) | MAP2K1IGF1REGFRIKBKBLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | disclosed |