Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 14/20 | 0.66 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841635 | 0.91 | ANO1 (0.54) | ANO1PRKDCKDM4EALDH1A1MAPT | |
| SCHEMBL2839959 | 0.85 | CYP3A4 (0.46) | ANO1PRKDC | |
| SCHEMBL2840409 | 0.85 | ANO1 (0.46) | ANO1PRKDC | |
| SCHEMBL2842319 | 0.83 | CYP3A4 (0.44) | ANO1PRKDCALDH1A1MAPTP2RY12 | |
| SCHEMBL2838819 | 0.83 | ANO1 (0.46) | ANO1PRKDCLMNAKDM4EALDH1A1 | |
| SCHEMBL2841409 | 0.82 | PRKDC (0.48) | ANO1PRKDCMAPT | |
| SCHEMBL2856691 | 0.82 | ANO1 (0.42) | ANO1PRKDCKDM4EALDH1A1MAPT | |
| SCHEMBL2836708 | 0.81 | ANO1 (0.42) | ANO1PRKDCKDM4EALDH1A1HPGD | |
| SCHEMBL2840266 | 0.80 | CYP3A4 (0.46) | ANO1PRKDC | |
| SCHEMBL2840261 | 0.80 | PRKDC (0.44) | ANO1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581207-A4 | BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES | VIROPHARMA INC (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1581207-A2 | BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES | Viropharma Incorporated (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004041201-A2 | BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES | VIROPHARMA INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |