Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738188 | 0.88 | MAPK13 (0.41) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5256916 | 0.87 | MAPK14 (0.37) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5739360 | 0.85 | MAPK14 (0.41) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5260056 | 0.85 | MAPK14 (0.44) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5257300 | 0.85 | RXFP1 (0.36) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5254308 | 0.84 | PRKD3 (0.40) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5256386 | 0.82 | PRKD3 (0.36) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5257500 | 0.81 | MAPK11 (0.35) | MAPK13MAPK12MAPK11MAPK14HSP90AA1 | |
| SCHEMBL5738335 | 0.81 | MAPK13 (0.40) | PRKD3CLK2DYRK1APRKD2PIM2 | |
| SCHEMBL5737454 | 0.80 | MAPK14 (0.38) | MAPK13MAPK12MAPK11MAPK14KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333833-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-10-24 | — | — | EP | disclosed |
| EP-1333833-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002059083-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-01 | — | — | WO | disclosed |