Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737454 | 0.93 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5738681 | 0.90 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5260056 | 0.90 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5740166 | 0.89 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4289881 | 0.88 | MAPK11 (0.34) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5256916 | 0.86 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4056370 | 0.86 | MAPK11 (0.34) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5256394 | 0.85 | PRKD3 (0.39) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5257500 | 0.83 | MAPK11 (0.35) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5738335 | 0.82 | MAPK13 (0.40) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499320-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | claimed |
| EP-1499320-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-01-26 | — | — | EP | claimed |
| WO-2003088972-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-30 | — | — | WO | claimed |
| EP-1499320-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-1499320-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003088972-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-30 | — | — | WO | disclosed |