Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778262 | 0.85 | KDM4E (0.52) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL257828 | 0.82 | HPGD (0.53) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL13985948 | 0.80 | ALDH1A1 (0.55) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL13977644 | 0.80 | ALDH1A1 (0.48) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL4816249 | 0.78 | HPGD (0.57) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL2618834 | 0.78 | KDM4E (0.49) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL11383131 | 0.78 | SCN4A (0.53) | ALDH1A1HPGDNPSR1LMNASMN1; SMN2 | |
| SCHEMBL12121221 | 0.77 | KDM4E (0.52) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL16358868 | 0.77 | AAK1 (0.53) | ALDH1A1POLBHPGDNPSR1LMNA | |
| SCHEMBL13642366 | 0.77 | KMT2A (0.50) | ALDH1A1POLBHPGDNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598500-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015972-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |