Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260551 | 0.89 | MAPT (0.36) | TSHRPOLBKMT2ALMNASTAT1 | |
| SCHEMBL5257146 | 0.81 | LMNA (0.52) | TSHRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL2535569 | 0.80 | LMNA (0.38) | POLBHSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL395325 | 0.76 | DHODH (0.46) | SMN1; SMN2MAPTALDH1A1TP53TDP1 | |
| SCHEMBL4147861 | 0.74 | GAA (0.43) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL1135020 | 0.73 | HDAC8 (0.41) | TSHRPOLBRECQLHSD17B10MEN1 | |
| SCHEMBL11201864 | 0.72 | GAA (0.44) | TSHRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL17963098 | 0.71 | LMNA (0.69) | TSHRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1245810 | 0.71 | GAA (0.43) | TSHRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4154250 | 0.71 | GAA (0.43) | POLBMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625127-B1 | AZAINDOLE COMPOUNDS AS KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2007-05-23 | — | — | EP | disclosed |
| US-20060287354-A1 | Azaindole compounds as kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287354-A1 | Azaindole compounds as kinase inhibitors | ABL1, CDK2, CDKN1A | TSHR 2419/4885POLB 2328/4885RECQL 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.