Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.36 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14266338 | 0.81 | MAPK14 (0.58) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL14266337 | 0.81 | MAPK14 (0.58) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL21621158 | 0.67 | MAPK14 (0.67) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL2942640 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL3028823 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL2943688 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL2944575 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL2939734 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL29634515 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL2939727 | 0.67 | MAPK14 (0.65) | MAPK14MAPK11MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685131-B1 | HYDROXYALKYL SUBSTITUTED PYRIDO-7-PYRIMIDIN-7-ONES | HOFFMANN LA ROCHE (CH) | 2007-03-07 | — | — | EP | disclosed |