Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219412 | 0.93 | SRC (0.58) | SRCEGFRGAKMAP2K1ERBB2 | |
| SCHEMBL3212382 | 0.90 | SRC (0.56) | SRCEGFRGAKMAP2K1 | |
| SCHEMBL3228051 | 0.89 | SRC (0.61) | SRCEGFRGAKMAP2K1 | |
| SCHEMBL3231791 | 0.88 | SRC (0.68) | SRCEGFRGAK | |
| SCHEMBL3222224 | 0.86 | SRC (0.51) | SRCEGFRGAKMAP2K1 | |
| SCHEMBL3221249 | 0.85 | SRC (0.54) | SRCEGFRGAK | |
| SCHEMBL3221516 | 0.85 | SRC (0.63) | SRCEGFRMAP2K1 | |
| SCHEMBL27570015 | 0.85 | SRC (0.42) | SRCEGFRGAKMAP2K1ERBB2 | |
| SCHEMBL5313344 | 0.84 | SRC (0.70) | SRCEGFRGAKMAP2K1 | |
| SCHEMBL3224394 | 0.81 | SRC (0.68) | SRCEGFRGAKMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100439340-C | 3-cyanoquinolines, 3-cyano-1, 6-naphthyridines, and 3-cyano-1, 7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2008-12-03 | — | — | CN | claimed |
| CN-1419545-A | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | claimed |
| CN-100439340-C | 3-cyanoquinolines, 3-cyano-1, 6-naphthyridines, and 3-cyano-1, 7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2008-12-03 | — | — | CN | disclosed |
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | disclosed |
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |
| CN-1419545-A | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | disclosed |
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |