Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082338 | 0.87 | MAPK8 (0.55) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4459782 | 0.83 | MAPK8 (0.53) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6904255 | 0.83 | MAPK8 (0.58) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6454278 | 0.82 | MAPK8 (0.49) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6904251 | 0.82 | MAPK8 (0.57) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4086682 | 0.82 | MAPK8 (0.52) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL8352585 | 0.79 | MAPK8 (0.53) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4082313 | 0.79 | MAPK8 (0.53) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4081804 | 0.76 | MAPK8 (0.63) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7313604 | 0.74 | MAPK8 (0.67) | MAPK8HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784224-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR TREATING RESPIRATORY AND GASTROINTESTINAL DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006015775-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR TREATING RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-16 | — | — | WO | disclosed |