Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307728 | 0.86 | MAPK8 (0.78) | MAPK8KMT2AHPGDALDH1A1 | |
| SCHEMBL6904255 | 0.83 | MAPK8 (0.58) | MAPK8KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL6904251 | 0.82 | MAPK8 (0.57) | MAPK8KMT2AHPGD | |
| SCHEMBL7310026 | 0.81 | MAPK8 (1.00) | MAPK8ALDH1A1 | |
| SCHEMBL4082338 | 0.81 | MAPK8 (0.55) | MAPK8KMT2AHPGD | |
| SCHEMBL7371941 | 0.80 | MAPK8 (0.65) | MAPK8KMT2AHPGDMEN1 | |
| SCHEMBL7319190 | 0.80 | MAPK8 (0.78) | MAPK8KMT2AHPGDALDH1A1 | |
| SCHEMBL8352585 | 0.79 | MAPK8 (0.53) | MAPK8KMT2AHPGD | |
| SCHEMBL7374630 | 0.79 | MAPK8 (0.58) | MAPK8KMT2AHPGD | |
| SCHEMBL7365059 | 0.79 | MAPK8 (0.58) | MAPK8KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |