Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.63 |
| ▸ | KIT | P10721 | 10/20 | 0.63 |
| ▸ | KDR | P35968 | 9/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.63 |
| ▸ | LCK | P06239 | 6/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953089 | 1.00 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952405 | 1.00 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2955019 | 1.00 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2947800 | 0.90 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2955274 | 0.81 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2948597 | 0.81 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952510 | 0.81 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954228 | 0.81 | MAPK14 (0.74) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2953078 | 0.81 | MAPK14 (0.78) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2949233 | 0.81 | MAPK14 (0.78) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006094187-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-09-08 | — | — | WO | claimed |