Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.36 |
| ▸ | ACACA | Q13085 | 5/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310133 | 0.86 | EPHB4 (0.38) | MAPK14 | |
| SCHEMBL5315338 | 0.86 | EPHB4 (0.38) | MAPK14 | |
| SCHEMBL6417723 | 0.85 | CFD (0.34) | MAPK14 | |
| SCHEMBL6415985 | 0.85 | ACACB (0.37) | ACACBACACACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL5914098 | 0.83 | MAPK14 (0.39) | ACACBACACACCKBRNAMPTCYP3A4 | |
| SCHEMBL5914093 | 0.83 | MAPK14 (0.39) | ACACBACACACCKBRNAMPTCYP3A4 | |
| SCHEMBL6431698 | 0.81 | KDR (0.41) | CYP3A4CYP2C9 | |
| SCHEMBL5914251 | 0.79 | BRD4 (0.38) | CYP3A4BRD4GLSMAPK14SCN9A | |
| SCHEMBL5914249 | 0.79 | BRD4 (0.38) | CYP3A4BRD4GLSMAPK14SCN9A | |
| SCHEMBL6415740 | 0.79 | KDR (0.33) | CYP3A4CYP2C9MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765825-A1 | CONDENSED TRIAZOLES AND INDAZOLES USEFUL IN TREATING CITOKINES MEDIATED DISEASES AND OTHER DISEASES | AMGEN INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004702-A1 | CONDENSED TRIAZOLES AND INDAZOLES USEFUL IN TREATING CITOKINES MEDIATED DISEASES AND OTHER DISEASES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |