⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3327764 | 0.98 | EPHX2 (0.33) | — | |
| SCHEMBL11596230 | 0.82 | PTPN1 (0.30) | — | |
| SCHEMBL13275068 | 0.80 | KDM4E (0.38) | — | |
| SCHEMBL185561 | 0.78 | — | — | |
| Potassium SCHEMBL834916 | 0.76 | PTPN1 (0.41) | — | |
| SCHEMBL22436525 | 0.76 | PTPN1 (0.41) | — | |
| SCHEMBL3355222 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL22436543 | 0.76 | PTPN1 (0.41) | — | |
| SCHEMBL7374599 | 0.74 | ALDH1A1 (0.42) | — | |
| Potassium Ion SCHEMBL52283 | 0.74 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404284-B2 | Spirocyclic inhibitors of hepatitis B virus | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2025-09-02 | — | — | US | disclosed |
| EP-4494709-A2 | SPIROCYCLIC INHIBITORS OF HEPATITIS B VIRUS | Ospedale San Raffaele S.r.l. (IT) | 2025-01-22 | — | — | EP | disclosed |
| US-20240368150-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | HOFFMANN-LA ROCHE INC. (US) | 2024-11-07 | — | — | US | disclosed |
| EP-4103567-B1 | SPIROCYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE SRL (IT) | 2024-10-23 | — | — | EP | disclosed |
| EP-3833672-B1 | TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE SRL (IT) | 2024-09-18 | — | — | EP | disclosed |
| CN-113272309-B | Tricyclic inhibitors of hepatitis b virus | 圣拉斐尔医院有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117447375-A | Guanidine compound, preparation method and application thereof | 中国医学科学院药物研究所 | 2024-01-26 | — | — | CN | disclosed |
| EP-4291558-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2023-12-20 | — | — | EP | disclosed |
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |
| US-20230151027-A1 | SPIROCYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2023-05-18 | — | — | US | disclosed |
| US-20070292504-A1 | Pharmaceutical formulation containing a release rate controlling composition | MERCK SHARP & DOHME LLC | 2007-12-20 | — | — | US | disclosed |
| US-20070259894-A1 | Use of Atazanavir for Improving the Pharmacokinetics of Drugs Metabolized by Ugt1a1 | MERCK SHARP & DOHME CORP. | 2007-11-08 | — | — | US | disclosed |
| US-20070259894-A1 | Use of Atazanavir for Improving the Pharmacokinetics of Drugs Metabolized by Ugt1a1 | MERCK SHARP & DOHME CORP. | 2007-11-08 | — | — | US | disclosed |
| WO-2007087188-A2 | TASTE-MASKED TABLETS AND GRANULES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2006060731-A2 | USE OF ATAZANAVIR FOR IMPROVING THE PHARMACOKINETICS OF DRUGS METABOLIZED BY UGT1A1 | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-4326065-A | PLASTICS, VARNISHES, POLYESTERS | EASTMAN KODAK COMPANY (US) | 1982-04-20 | — | — | US | disclosed |
| US-4251433-A | BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS | EASTMAN KODAK COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4236013-A | ADDITIVES FOR POLYMERS | EASTMAN KODAK COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4137235-A | ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS | EASTMAN KODAK COMPANY (US) | 1979-01-30 | — | — | US | disclosed |
| US-4116928-A | Heterocylic ester, ultraviolet stabilizers and their use in organic compositions | EASTMAN KODAK COMPANY (US) | 1978-09-26 | — | — | US | disclosed |