Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.76 |
| ▸ | CDK2 | P24941 | 10/20 | 0.76 |
| ▸ | KDR | P35968 | 6/20 | 0.76 |
| ▸ | IGF1R | P08069 | 4/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938954 | 0.86 | CDK1 (1.00) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL5258869 | 0.86 | CDK1 (0.77) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL4459525 | 0.83 | IGF1R (1.00) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL5257636 | 0.80 | CA2 (0.71) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL14336430 | 0.80 | TNNI3K (0.59) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL4577979 | 0.80 | CDK2 (0.71) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL24477881 | 0.79 | CDK1 (0.58) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL4062771 | 0.79 | CA2 (0.54) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL5261726 | 0.79 | IGF1R (0.85) | CDK1CDK2KDRIGF1RGSK3B | |
| SCHEMBL4062176 | 0.78 | CDK1 (0.63) | CDK1CDK2KDRCCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272477-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2007-05-09 | — | — | EP | claimed |
| US-7153964-B2 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2006-12-26 | — | — | US | claimed |
| JP-2003525277-A | — | — | 2003-08-26 | — | — | JP | claimed |
| US-20030149064-A1 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | US | claimed |
| EP-1272477-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2003-01-08 | — | — | EP | claimed |
| WO-2001064654-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-09-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149064-A1 | Pyrimidine compounds | CDK2, CCNI, CCNY | CDK1 6/4885CDK2 1/4885KDR 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.