Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14498817 | 0.90 | KCNH2 (0.50) | PDGFRBKDRKCNH2MEN1KMT2A | |
| SCHEMBL5264336 | 0.82 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL5261779 | 0.80 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL14498889 | 0.78 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL14523985 | 0.77 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL14341258 | 0.77 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL14341455 | 0.77 | KCNH2 (0.65) | KCNH2 | |
| SCHEMBL4041903 | 0.76 | TRPV1 (0.43) | — | |
| SCHEMBL5261919 | 0.76 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL5263873 | 0.71 | KCNH2 (0.52) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399443-B1 | NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2007-12-12 | — | — | EP | claimed |