Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261931 | 0.98 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5258988 | 0.88 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607763 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607754 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL23928929 | 0.85 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL4764454 | 0.83 | PIK3CD (0.49) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607142 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5606983 | 0.82 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL356968 | 0.81 | PIK3CD (0.50) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL357687 | 0.81 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | claimed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | claimed |
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |