Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.51 |
| ▸ | HTR1D | P28221 | 12/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.51 |
| ▸ | HTR1B | P28222 | 10/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL425995 | 0.99 | HTR1A (0.50) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL430293 | 0.93 | HTR1A (0.51) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL10212541 | 0.92 | HTR1A (0.55) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| Ammonia Solution, Strong SCHEMBL430279 | 0.91 | HTR1A (0.54) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL429284 | 0.91 | HTR1A (0.53) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL10212574 | 0.91 | HTR1A (0.53) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| Hydrochloric Acid SCHEMBL428492 | 0.90 | HTR1A (0.53) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL427160 | 0.87 | HTR1A (0.51) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL430216 | 0.86 | HTR1A (0.51) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| Hydrochloric Acid SCHEMBL430255 | 0.86 | HTR1A (0.51) | HTR1AHTR1DSLC6A4KCNH2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |