⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27925379 | 0.75 | — | — | |
| SCHEMBL11285803 | 0.75 | — | — | |
| SCHEMBL19705265 | 0.75 | — | — | |
| SCHEMBL750822 | 0.75 | — | — | |
| SCHEMBL27925399 | 0.75 | — | — | |
| SCHEMBL130245 | 0.72 | — | — | |
| Ammonia Solution, Strong SCHEMBL15795891 | 0.70 | NOS3 (0.39) | — | |
| SCHEMBL27943884 | 0.70 | KCNJ1 (0.33) | — | |
| SCHEMBL27730537 | 0.69 | KMT2A (0.36) | — | |
| SCHEMBL750795 | 0.69 | POLB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178693-A1 | METHOD FOR PREPARING LEMBOREXANT AND METHOD FOR PREPARING LEMBOREXANT INTERMEDIATE | 浙江华海药业股份有限公司 | 2023-09-28 | — | — | WO | disclosed |
| EP-1500657-B1 | Substituted pyrazoles as P38 kinase inhibitors | SEARLE LLC (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
| US-7153959-B2 | treatment of tumor necrosis factor mediated disorders; asthma; inflammatory bowel disease; arthritis | PHARMACIA CORPORATION (US) | 2006-12-26 | — | — | US | disclosed |
| US-7071198-B1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |
| US-6979686-B1 | Substituted pyrazoles as p38 kinase inhibitors | PHARMACIA CORPORATION (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1500657-A1 | Substituted pyrazoles as P38 kinase inhibitors | G.D. Searle LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1144403-B1 | SUBSTITUTED PYRAZOLES AS P38 KINASE INHIBITORS | SEARLE LLC (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20040176433-A1 | treatment of tumor necrosis factor mediated disorders; asthma; inflammatory bowel disease; arthritis | PHARMACIA CORPORATION | 2004-09-09 | — | — | US | disclosed |
| US-6639109-B1 | Reacting amino alcohol with sulfuric acid then reacting resulting amino sulfate with a mercaptan; simple, safe, rapid | NIHON NOHYAKU CO., LTD. (JP) | 2003-10-28 | — | — | US | disclosed |
| EP-1216988-A1 | THIOALKYLAMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Nihon Nohyaku Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
| EP-0291304-B1 | PROCESS FOR THE CONVERSION OF THE E-ISOMER OF 6-(SUBSTITUTED METHYLENE)-2-PENEMS INTO THE Z-ISOMER | BEECHAM GROUP PLC (GB) | 1992-02-26 | — | — | EP | disclosed |
| EP-0167980-B1 | NOVEL SUBSTRATES FOR USE IN MEASURING THE CONCENTRATION OF KALLIKREIN IN URINE | NITTO BOSEKI CO., LTD. (JP) | 1991-08-07 | — | — | EP | disclosed |
| US-4897476-A | Process for preparing penems | BEECHAM GROUP P.L.C. (GB) | 1990-01-30 | — | — | US | disclosed |
| EP-0291304-A1 | Process for the conversion of the E-isomer of 6-(substituted methylene)-2-penems into the Z-isomer | BEECHAM GROUP PLC (GB) | 1988-11-17 | — | — | EP | disclosed |
| US-4650753-A | Novel substrates for use in measuring the concentration of kallikrein in urine | NITTO BOSEKI CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0167980-A2 | Novel substrates for use in measuring the concentration of kallikrein in urine | NITTO BOSEKI CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |