Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 10/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263029 | 0.89 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5264169 | 0.89 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5261206 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL357206 | 0.86 | PIK3CD (0.46) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL5260944 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5261257 | 0.77 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL5262936 | 0.75 | PIK3CD (0.35) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL1637876 | 0.74 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL356477 | 0.74 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL5262939 | 0.74 | PIK3CD (0.34) | PIK3CDPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |