Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264169 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5261206 | 0.90 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5260703 | 0.89 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGTMIGD3 | |
| SCHEMBL5260944 | 0.88 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5262936 | 0.85 | PIK3CD (0.35) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL1637876 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5262939 | 0.84 | PIK3CD (0.34) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL5261257 | 0.80 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL356477 | 0.77 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL356182 | 0.77 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |