Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.69 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | CETP | P11597 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | GMNN | O75496 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.69 |
| ▸ | CCR6 | P51684 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | UBE2N | P61088 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12966636 | 1.00 | SPHK2 (0.69) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL12922735 | 1.00 | SPHK2 (0.69) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL27705510 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL1133995 | 0.88 | SPHK2 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL28772557 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL312332 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL4608213 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL5616499 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL27491463 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP | |
| SCHEMBL9112746 | 0.88 | MEN1 (0.65) | SPHK2SPHK1MEN1KMT2ACETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116875609-A | Spherical nucleic acid targeting TLR9 with potent antitumor activity | 埃克西奎雷运营公司 | 2023-10-13 | — | — | CN | claimed |
| EP-4228667-A1 | METHODS FOR REVERSING HEPATIC STEATOSIS | Brightseed, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| CN-116568319-A | Method for reversing hepatic steatosis | 布莱特西德公司 | 2023-08-08 | — | — | CN | claimed |
| WO-2022081567-A1 | METHODS FOR REVERSING HEPATIC STEATOSIS | BRIGHTSEED, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-2598126-A2 | METHODS OF TREATING PAIN | Saint Louis University (US) | 2013-06-05 | — | — | EP | claimed |
| EP-2438445-A1 | MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS | Metanomics Health GmbH (DE) | 2012-04-11 | — | — | EP | claimed |
| US-20120039866-A1 | METHODS OF TREATING PAIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-16 | — | — | US | claimed |
| WO-2012015758-A2 | METHODS OF TREATING PAIN | SAINT LOUIS UNIVERSITY (US) | 2012-02-02 | — | — | WO | claimed |
| WO-2010139711-A1 | MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS | METANOMICS HEALTH GMBH (DE) | 2010-12-09 | — | — | WO | claimed |
| US-20030119789-A1 | Compositions and methods for treating autoimmune disease | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2003-06-26 | — | — | US | claimed |
| US-6518259-B1 | Compositions for treating autoimmune disease | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2003-02-11 | — | — | US | claimed |
| WO-2003005965-A2 | MODULATORS OF CERAMIDASE AND METHODS OF USE BASED THEREON | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2003-01-23 | — | — | WO | claimed |
| US-20010041688-A1 | Methods and compositions for the regulation of vasoconstriction | GENERAL HOSPITAL CORPORATION, THE | 2001-11-15 | — | — | US | claimed |
| WO-2001069252-A1 | METHODS AND COMPOSITIONS FOR THE REGULATION OF VASOCONSTRICTION | THE GENERAL HOSPITAL CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
| US-6098631-A | Compositions and methods for treating autoimmune disease | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2000-08-08 | — | — | US | claimed |
| WO-1999037298-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1999-07-29 | — | — | WO | claimed |
| EP-0381514-B1 | Use of N-methyl-sphingosine as inhibitor of cell growth | BIOMEMBRANE INST (US) | 1995-05-17 | — | — | EP | claimed |
| EP-0381514-A2 | Use of N-methyl-sphingosine as inhibitor of cell growth | The Biomembrane Institute (US) | 1990-08-08 | — | — | EP | claimed |
| JP-2215711-A | — | — | None | — | — | JP | disclosed |
| EP-0381514-A2 | Use of N-methyl-sphingosine as inhibitor of cell growth | The Biomembrane Institute (US) | 1990-08-08 | — | — | EP | disclosed |