Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310730 | 0.87 | GRM5 (0.57) | GRM5FFAR1KCNH2CYP1A2 | |
| SCHEMBL5703277 | 0.84 | FFAR1 (0.50) | GRM5FFAR1FFAR4 | |
| SCHEMBL5256988 | 0.83 | GRM5 (0.65) | GRM5PDE10A | |
| SCHEMBL102791 | 0.81 | GRM5 (0.50) | GRM5FFAR1FFAR4KCNH2EGFR | |
| SCHEMBL5258625 | 0.80 | GRM5 (0.66) | GRM5 | |
| SCHEMBL31036128 | 0.78 | GRM5 (0.45) | GRM5FFAR1KCNH2CYP1A2 | |
| SCHEMBL101862 | 0.78 | GRM5 (0.45) | GRM5FFAR1KCNH2CYP1A2 | |
| SCHEMBL408472 | 0.78 | GRM5 (0.49) | GRM5KCNH2CYP1A2 | |
| SCHEMBL102810 | 0.78 | GRM5 (0.45) | GRM5FFAR1KCNH2CYP1A2 | |
| SCHEMBL103493 | 0.78 | LMNA (0.56) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | claimed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |