Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580790 | 0.88 | ALDH1A1 (0.49) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL5147100 | 0.85 | ALDH1A1 (0.47) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL4581265 | 0.83 | ALDH1A1 (0.53) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL4578733 | 0.83 | GRM5 (0.54) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL4581515 | 0.82 | ALDH1A1 (0.42) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL4581450 | 0.80 | ALDH1A1 (0.44) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL14266821 | 0.77 | ALDH1A1 (0.55) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL4579023 | 0.73 | ALDH1A1 (0.50) | TDP1KMT2AALDH1A1MEN1PKM | |
| SCHEMBL4580503 | 0.72 | ALDH1A1 (0.52) | TDP1KMT2AALDH1A1MEN1SCN9A | |
| SCHEMBL14266823 | 0.71 | ALDH1A1 (0.59) | TDP1KMT2AALDH1A1MEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773834-A2 | 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES | Serenex, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006017672-A2 | 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES | SERENEX INC. (US) | 2006-02-16 | — | — | WO | claimed |