Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 11/20 | 0.67 |
| ▸ | KDR | P35968 | 9/20 | 0.67 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261124 | 0.87 | KDR (0.72) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL5263460 | 0.85 | TEK (0.55) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1264888 | 0.80 | TEK (1.00) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL4792941 | 0.78 | TEK (0.83) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1264150 | 0.77 | TEK (0.77) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1265014 | 0.77 | TEK (0.82) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1263743 | 0.75 | TEK (0.91) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1264985 | 0.74 | KDR (0.59) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1265681 | 0.73 | TEK (0.85) | TEKKDRLCKBRAFMAPK14 | |
| SCHEMBL1264096 | 0.73 | TEK (0.85) | TEKKDRLCKBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |