Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 11/20 | 0.58 |
| ▸ | HPN | P05981 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | C1S | P09871 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2816912 | 0.84 | C1R (0.69) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL4194659 | 0.84 | C1R (0.72) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL5257308 | 0.84 | C1R (0.72) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL9475739 | 0.79 | C1R (0.76) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL5921548 | 0.79 | C1R (0.55) | C1RKMT2APRSS1MAPTGAA | |
| SCHEMBL17870594 | 0.78 | C1R (0.74) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL5437118 | 0.77 | F7 (0.56) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL4202365 | 0.76 | MEN1 (0.75) | C1RKMT2APRSS1MAPTMEN1 | |
| SCHEMBL4194349 | 0.76 | APEX1 (0.72) | C1RKMT2AF2PLGKLK1 | |
| SCHEMBL17554083 | 0.75 | APEX1 (0.76) | C1RKMT2AF2PLGKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |