Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 11/20 | 0.72 |
| ▸ | APEX1 | P27695 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | C1S | P09871 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194349 | 0.89 | APEX1 (0.72) | C1RAPEX1ALDH1A1KDM4EELANE | |
| SCHEMBL2816912 | 0.84 | C1R (0.69) | C1RALDH1A1KDM4EELANEPRSS1 | |
| SCHEMBL4194659 | 0.84 | C1R (0.72) | C1RALDH1A1KDM4EELANEPRSS1 | |
| SCHEMBL914556 | 0.84 | C1R (0.72) | C1RAPEX1ALDH1A1KDM4EELANE | |
| SCHEMBL5261384 | 0.84 | C1R (0.58) | C1RAPEX1ALDH1A1PRSS1F2 | |
| SCHEMBL2704120 | 0.81 | C1R (0.68) | C1RAPEX1ALDH1A1KDM4EELANE | |
| SCHEMBL9475739 | 0.79 | C1R (0.76) | C1RALDH1A1KDM4EELANEPRSS1 | |
| SCHEMBL2328301 | 0.78 | ALDH1A1 (0.63) | C1RAPEX1ALDH1A1KDM4EELANE | |
| SCHEMBL916032 | 0.78 | C1R (0.74) | C1RAPEX1ALDH1A1KDM4EELANE | |
| SCHEMBL5921767 | 0.78 | C1R (0.63) | C1RAPEX1ALDH1A1KDM4EELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |