Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 2/20 | 0.42 |
| ▸ | CALCRL | Q16602 | 18/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | RAMP1 | O60894 | 6/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256857 | 0.93 | CALCRL (0.40) | CALCACALCRLCYP3A4RAMP1CTSB | |
| SCHEMBL5260143 | 0.91 | CALCA (0.45) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5258039 | 0.91 | CALCA (0.44) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5257817 | 0.90 | CALCA (0.42) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL3871116 | 0.90 | CALCA (0.53) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5260681 | 0.90 | CALCA (0.46) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5261246 | 0.90 | CALCA (0.42) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5256292 | 0.89 | CALCA (0.45) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL5259634 | 0.89 | CALCA (0.39) | CALCACALCRLCYP3A4RAMP1 | |
| SCHEMBL3874855 | 0.83 | CALCA (0.49) | CALCACALCRLCYP3A4RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487821-B1 | BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-03-21 | — | — | EP | disclosed |
| EP-1487821-A1 | BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003076432-A1 | BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-09-18 | — | — | WO | disclosed |