Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784044 | 0.88 | NPC1 (0.65) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL17784035 | 0.88 | NPC1 (0.57) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL21145815 | 0.84 | NPC1 (0.52) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL2302662 | 0.84 | KCNQ3 (0.64) | MEN1KMT2AMAPTRAB9ALMNA | |
| SCHEMBL17784117 | 0.83 | KCNQ3 (0.51) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL4437537 | 0.80 | MAPT (0.68) | MEN1KMT2AMAPTRAB9ALMNA | |
| SCHEMBL14874999 | 0.80 | RAB9A (0.51) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL19479144 | 0.80 | NPC1 (0.67) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL13455669 | 0.79 | NPC1 (0.68) | NPC1MEN1KMT2AMAPTLMNA | |
| SCHEMBL22059501 | 0.79 | HDAC8 (0.47) | NPC1MEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094187-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-09-08 | — | — | WO | disclosed |