Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 13/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262126 | 0.92 | KCNH2 (0.42) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5262428 | 0.90 | KCNH2 (0.40) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5261839 | 0.89 | KCNH2 (0.56) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5265531 | 0.88 | KCNH2 (0.56) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5265526 | 0.88 | KCNH2 (0.56) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5261875 | 0.86 | KCNH2 (0.46) | KCNH2POLBTOP2ATOP2BCHRM2 | |
| SCHEMBL5262121 | 0.81 | KCNH2 (0.55) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9377018 | 0.81 | KCNH2 (0.47) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5261012 | 0.81 | KCNH2 (0.54) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5261003 | 0.81 | KCNH2 (0.54) | KCNH2CACNA1FPOLBMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187835-B1 | OPTICALLY ACTIVE QUINOLINE CARBOXYLIC ACID DERIVATIVES HAVING 7-PYRROLIDINE SUBSTITUTES CAUSING OPTICAL ACTIVITY AND A PROCESS FOR PREPARING THEREOF | DONG WHA PHARM IND CO LTD (KR) | 2007-12-26 | — | — | EP | claimed |