Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 15/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262428 | 0.93 | KCNH2 (0.40) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5261841 | 0.92 | KCNH2 (0.43) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5262121 | 0.89 | KCNH2 (0.55) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5261012 | 0.89 | KCNH2 (0.54) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5261008 | 0.89 | KCNH2 (0.54) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5261003 | 0.89 | KCNH2 (0.54) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL5262424 | 0.82 | KCNH2 (0.52) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9377018 | 0.81 | KCNH2 (0.47) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5263111 | 0.81 | KCNH2 (0.51) | KCNH2CACNA1FPOLBMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL5263101 | 0.81 | KCNH2 (0.51) | KCNH2CACNA1FPOLBMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187835-B1 | OPTICALLY ACTIVE QUINOLINE CARBOXYLIC ACID DERIVATIVES HAVING 7-PYRROLIDINE SUBSTITUTES CAUSING OPTICAL ACTIVITY AND A PROCESS FOR PREPARING THEREOF | DONG WHA PHARM IND CO LTD (KR) | 2007-12-26 | — | — | EP | claimed |