Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333780 | 0.81 | HPGD (0.40) | KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL20819459 | 0.75 | AKT1 (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL20819458 | 0.75 | AKT1 (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL20822102 | 0.74 | PTGS1 (0.38) | KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL20822184 | 0.73 | KDM4E (0.31) | KDM4EALDH1A1HPGD | |
| SCHEMBL20822185 | 0.73 | AKT1 (0.41) | KDM4EALDH1A1HPGD | |
| SCHEMBL4466778 | 0.71 | AKT1 (0.53) | — | |
| SCHEMBL20822100 | 0.71 | CYP3A4 (0.36) | KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL657575 | 0.69 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL14706561 | 0.69 | KDM4E (0.35) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | claimed |