Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387746 | 0.89 | GPR119 (0.77) | GPR119ALDH1A1MAPTTDP1CTSB | |
| SCHEMBL5263313 | 0.87 | GPR119 (0.79) | GPR119ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5266036 | 0.86 | GPR119 (0.53) | GPR119ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5259360 | 0.85 | GPR119 (0.60) | GPR119ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL1673955 | 0.85 | GPR119 (0.57) | GPR119ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5263490 | 0.85 | GPR119 (0.45) | GPR119ALDH1A1MAPTCTSBMEN1 | |
| SCHEMBL5262728 | 0.83 | GPR119 (0.61) | GPR119ALDH1A1MAPTACACBCTSB | |
| SCHEMBL5267022 | 0.83 | GPR119 (0.47) | GPR119ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6041145 | 0.82 | GPR119 (0.49) | GPR119 | |
| SCHEMBL4705303 | 0.81 | GPR119 (0.53) | GPR119ALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |